abstract：:A comparative study of high-dose (HD, carbimazole 60 mg plus thyroxine 100-150 micrograms daily) and titration-dose (TD) regimens of carbimazole was carried out in 70 patients with Graves' disease, the patients being assigned randomly to one or other regimen. The treatment was given for 1 year and follow-up was for 2 ...

journal_title：European journal of endocrinology

authors： Edmonds CJ,Tellez M

更新日期：1994-08-01 00:00:00

abstract：:Thirteen patients with active acromegaly despite previous surgery were treated with 30 mg lanreotide im twice a month for 9 months. In 10 subjects the treatment continued to 19 months. GH serum levels of all patients decreased significantly from an initial value of 32.0 (29.4) micrograms/l [median (standard error of m...

journal_title：European journal of endocrinology

authors： Marek J,Hána V,Krsek M,Justová V,Catus F,Thomas F

更新日期：1994-07-01 00:00:00

abstract：:Kidney dysfunction has been observed in aged humans and rats, the primary cause of which may reside in the kidney itself or in the hypothalamus. The latter possibility is suggested by the increased release of AVP in response to salt infusion in humans. The effect of age on the relationship between plasma osmolality an...

journal_title：European journal of endocrinology

authors： Terwel D,Jolles J

更新日期：1994-07-01 00:00:00

abstract：:Several bone matrix protein constituents, including the major component collagen type I and the hydroxyapatite binding protein, osteocalcin, have been implicated in the regulation of bone turnover. Cortical bone osteocalcin, collagen and mineral content were studied in autosomal dominant osteopetrosis type I (ADO), a ...

journal_title：European journal of endocrinology

authors： Bollerslev J,Marks SC Jr,Mosekilde L,Lian JB,Stein GS,Mosekilde L

更新日期：1994-06-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) exerts various effects on many cell types. Acute administration of TNF-alpha to rats decrease hepatic 5'-deiodinase activity (5'D-I) and TNF-alpha has been implicated in the pathogenesis of the low triiodothyronine syndrome in non-thyroidal illness in humans. The thyroid, liver ...

journal_title：European journal of endocrinology

authors： Ongphiphadhanakul B,Fang SL,Tang KT,Patwardhan NA,Braverman LE

更新日期：1994-05-01 00:00:00

abstract：:The relationship between calcitrophic hormones and blood pressure has been investigated in 583 elderly subjects who were untreated for hypertension. Univariate analysis demonstrated that serum parathyroid hormone, calcitriol, albumin and calcium were correlated significantly with mean blood pressure (r = +0.15, +0.10,...

journal_title：European journal of endocrinology

authors： St John A,Dick I,Hoad K,Retallack R,Welborn T,Prince R

更新日期：1994-05-01 00:00:00

abstract：:Glucocorticoid treatment causes osteoporosis and growth retardation in humans. Insulin-like growth factor I (IGF-I) stimulates differentiation and replication of cultured osteoblast-like cells and induces longitudinal bone growth in IGF-I-deficient rats. We investigated the influence of subcutaneously infused IGF-I on...

journal_title：European journal of endocrinology

authors： Binz K,Schmid C,Bouillon R,Froesch ER,Jürgensen K,Hunziker EB

更新日期：1994-04-01 00:00:00

abstract：:The aim of this study was to assess the usefulness of ketoconazole as a therapeutic alternative to polycystic ovary syndrome. The study group comprised 37 women with signs of hyperandrogenism (hirsutism, acne) and oligomenorrhea. A low dose (400 mg/day) of ketoconazole was tested in a 9-month prospective clinical stud...

journal_title：European journal of endocrinology

authors： Vidal-Puig AJ,Muñoz-Torres M,Jódar-Gimeno E,García-Calvente CJ,Lardelli P,Ruiz-Requena ME,Escobar-Jiménez F

更新日期：1994-04-01 00:00:00

abstract：:We have identified and characterized insulin-like growth factor I (IGF-I) and IGF-II/mannose-6-phosphate (IGF-II/M6P) receptors in bovine adrenal cells. Iodine-125-labeled IGF-I ([125I]IGF-I) binding was characteristic of the IGF-I receptor, and binding kinetics as well as receptor densities were similar in cortical a...

journal_title：European journal of endocrinology

authors： Weber MM,Kiess W,Beikler T,Simmler P,Reichel M,Adelmann B,Kessler U,Engelhardt D

更新日期：1994-03-01 00:00:00

abstract：:Ionomycin, which mobilizes Ca2+, and phorbol 12-myristate 13-acetate (PMA), which activates protein kinase C (PKC), were used to compare the effects/interactions of Ca2+ and PKC on luteinizing hormone (LH) secretion from pituitaries of intact male and acutely ovariectomized (72 h) rats. Quartered pituitaries from dono...

journal_title：European journal of endocrinology

authors： Das S,Fahmy NW,Bourne GA

更新日期：1994-02-01 00:00:00

abstract：:We report our experience in treating growth delay in boys with isolated growth hormone deficiency (IGHD) receiving biosynthetic human growth hormone. The study was performed in 15 boys with IGHD receiving GH. At the chronological age of 13.1 (1.1) years (SD), 13 were prepubertal, two were in early puberty and there wa...

journal_title：European journal of endocrinology

authors： Albanese A,Stanhope R

更新日期：1994-01-01 00:00:00

abstract：:In the last few years, molecular studies on pituitary adenomas have yielded evidence supporting a primary pituitary origin of these tumors. Although the existence of genomic alterations in tumoral cells is strongly suggested by the fact that almost all pituitary adenomas are monoclonal in origin, structural genetic ab...

journal_title：European journal of endocrinology

authors： Spada A,Vallar L,Faglia G

更新日期：1994-01-01 00:00:00